| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Justin Morneau | PIT | LAD | Sept. 16, 2008 | 16-19 | 5 | 5 | 7 | 3 | 3 | 1 | 130 |
| 2 | Scott Rolen | MIN | KC | April 4, 2008 | 12-6 | 5 | 5 | 6 | 2 | 4 | 0 | 120 |
| 3 | Jason Bay | LAD | PHI | Aug. 24, 2008 | 13-3 | 5 | 4 | 6 | 3 | 4 | 1 | 118 |
| 4 | Travis Hafner | OAK | KC | April 20, 2008 | 11-0 | 5 | 5 | 5 | 3 | 4 | 0 | 118 |
| 5 | Brad Eldred | ARI | FLO | Aug. 24, 2008 | 15-9 | 4 | 3 | 6 | 3 | 4 | 2 | 115 |
| 6 | Carlos Lee | NYM | CHC | April 22, 2008 | 13-6 | 4 | 3 | 8 | 2 | 3 | 0 | 107 |
| 7 | Aaron Rowand | SF | PHI | May 9, 2008 | 10-9 | 7 | 6 | 5 | 1 | 3 | 0 | 105 |
| 8 | John Shelby Jr. | PIT | LAD | Sept. 16, 2008 | 16-19 | 4 | 3 | 5 | 2 | 4 | 2 | 103 |
| 9 | Brett Dowdy | LAD | COL | July 23, 2008 | 10-8 | 4 | 3 | 6 | 3 | 3 | 1 | 103 |
| 10 | Paul Konerko | MIN | DET | May 4, 2008 | 11-9 | 4 | 4 | 5 | 3 | 3 | 0 | 103 |
| 11 | Josh Bonifay | BAL | MIN | Sept. 14, 2008 | 15-7 | 4 | 3 | 5 | 3 | 4 | 1 | 103 |
| 12 | Matt Hagen | HOU | MIL | May 3, 2008 | 11-4 | 5 | 3 | 7 | 3 | 3 | 0 | 101 |
| 13 | Alex Rodriguez | SF | LAD | March 31, 2008 | 9-6 | 5 | 5 | 4 | 2 | 3 | 0 | 99 |
| 14 | Dee Brown | CWS | CLE | May 28, 2008 | 10-6 | 4 | 4 | 5 | 2 | 3 | 0 | 98 |
| 15 | Matt Hagen | HOU | MIL | July 26, 2008 | 18-6 | 4 | 3 | 6 | 2 | 3 | 1 | 98 |
| 16 | Hideki Matsui | HOU | MIL | May 30, 2008 | 14-4 | 6 | 5 | 6 | 1 | 2 | 0 | 97 |
| 17 | Jake Ritchie | FLO | WAS | April 20, 2008 | 6-7 | 4 | 4 | 5 | 2 | 2 | 1 | 96 |
| 18 | Aubrey Huff | BOS | TEX | Sept. 5, 2008 | 13-9 | 4 | 4 | 3 | 1 | 4 | 2 | 96 |
| 19 | Matt Holliday | LAA | OAK | Aug. 26, 2008 | 13-6 | 4 | 4 | 5 | 2 | 2 | 1 | 96 |
| 20 | Prince Fielder | PIT | HOU | July 22, 2008 | 8-5 | 4 | 3 | 4 | 3 | 4 | 1 | 96 |
| 21 | Juan Uribe | PIT | LAD | April 15, 2008 | 9-7 | 4 | 4 | 3 | 2 | 4 | 1 | 96 |
| 22 | Alex Rodriguez | SF | STL | April 20, 2008 | 14-10 | 5 | 3 | 7 | 2 | 2 | 1 | 94 |
| 23 | Derry Hammond | ATL | FLO | Aug. 28, 2008 | 13-1 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 24 | Jacoby Ellsbury | NYY | OAK | July 19, 2008 | 13-4 | 5 | 5 | 3 | 1 | 4 | 0 | 94 |
| 25 | Adrian Beltre | STL | MIL | April 15, 2008 | 8-11 | 5 | 4 | 4 | 2 | 4 | 0 | 94 |
| 26 | Jose Guillen | TEX | LAA | April 14, 2008 | 14-7 | 5 | 4 | 4 | 2 | 4 | 0 | 94 |
| 27 | Matt Hagen | HOU | CHC | July 18, 2008 | 13-7 | 3 | 3 | 3 | 2 | 4 | 2 | 93 |
| 28 | Josh Willingham | PHI | STL | July 8, 2008 | 8-5 | 4 | 4 | 5 | 1 | 3 | 0 | 93 |
| 29 | Jake Ritchie | FLO | ARI | Aug. 24, 2008 | 9-15 | 2 | 2 | 4 | 2 | 4 | 2 | 92 |
| 30 | Jose Garcia | KC | MIN | Sept. 9, 2008 | 9-2 | 2 | 2 | 6 | 2 | 2 | 2 | 92 |