| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cole Hamels | PHI | WAS | March 31, 2008 | 2-0 | 9.0 | 0 | 0 | 0 | 3 | 11 | 99 |
| 2 | Clint Nageotte | BAL | MIL | June 21, 2008 | 10-0 | 9.0 | 0 | 4 | 0 | 0 | 12 | 98 |
| 3 | Josh Karp | HOU | MIL | July 25, 2008 | 10-0 | 9.0 | 0 | 2 | 0 | 1 | 10 | 98 |
| 4 | A J Burnett | OAK | MIN | Aug. 29, 2008 | 11-0 | 9.0 | 0 | 2 | 0 | 0 | 8 | 98 |
| 5 | Jake Peavy | BOS | ARI | June 24, 2008 | 8-0 | 9.0 | 0 | 2 | 0 | 1 | 8 | 96 |
| 6 | Travis Beazley | BAL | NYY | May 27, 2008 | 2-0 | 9.0 | 0 | 1 | 0 | 1 | 6 | 96 |
| 7 | Philip Wilson | COL | CHC | April 23, 2008 | 1-0 | 9.0 | 0 | 4 | 0 | 2 | 14 | 96 |
| 8 | Philip Wilson | COL | WAS | Aug. 4, 2008 | 6-1 | 9.0 | 1 | 3 | 0 | 2 | 15 | 96 |
| 9 | Emilis Guerrero | CHC | CIN | July 9, 2008 | 4-0 | 9.0 | 0 | 1 | 0 | 1 | 5 | 95 |
| 10 | Shaun Marcum | MIN | KC | April 5, 2008 | 3-0 | 9.0 | 0 | 3 | 0 | 0 | 7 | 95 |
| 11 | James Shields | LAD | HOU | May 10, 2008 | 6-0 | 9.0 | 0 | 3 | 0 | 2 | 10 | 94 |
| 12 | Jon Kibler | TB | HOU | June 21, 2008 | 9-0 | 9.0 | 0 | 2 | 0 | 2 | 8 | 94 |
| 13 | Carlos Villanueva | WAS | FLO | May 9, 2008 | 6-0 | 9.0 | 0 | 2 | 0 | 2 | 8 | 94 |
| 14 | Dontrelle Willis | DET | KC | May 15, 2008 | 5-0 | 9.0 | 0 | 2 | 0 | 2 | 8 | 94 |
| 15 | Adam Wainwright | TOR | BOS | Aug. 17, 2008 | 2-0 | 9.0 | 0 | 0 | 0 | 2 | 3 | 93 |
| 16 | Felix Hernandez | FLO | MIL | May 7, 2008 | 12-0 | 9.0 | 0 | 4 | 0 | 3 | 13 | 93 |
| 17 | P.J. Walters | COL | HOU | April 20, 2008 | 6-0 | 9.0 | 0 | 3 | 0 | 0 | 5 | 93 |
| 18 | Yusmeiro Petit | CHC | WAS | April 27, 2008 | 2-3 | 8.0 | 0 | 4 | 0 | 0 | 13 | 93 |
| 19 | Ismael Aranguren | LAA | DET | April 26, 2008 | 4-0 | 9.0 | 0 | 1 | 0 | 2 | 5 | 93 |
| 20 | Carlos Villanueva | WAS | STL | June 5, 2008 | 6-0 | 9.0 | 0 | 3 | 0 | 2 | 9 | 93 |
| 21 | Gerrit Simpson | KC | TEX | Aug. 26, 2008 | 7-0 | 9.0 | 0 | 2 | 0 | 2 | 6 | 92 |
| 22 | Yusmeiro Petit | CHC | PHI | April 11, 2008 | 6-1 | 8.1 | 0 | 4 | 0 | 0 | 10 | 92 |
| 23 | Adam Wainwright | TOR | CHC | June 14, 2008 | 4-1 | 8.0 | 0 | 2 | 0 | 0 | 8 | 92 |
| 24 | Zack Greinke | NYY | TOR | Aug. 21, 2008 | 1-0 | 9.0 | 0 | 7 | 0 | 0 | 12 | 92 |
| 25 | Cole Hamels | PHI | MIL | Sept. 13, 2008 | 3-5 | 8.0 | 0 | 4 | 0 | 0 | 12 | 92 |
| 26 | Jarrett Gardner | ARI | DET | May 17, 2008 | 12-0 | 9.0 | 0 | 3 | 0 | 0 | 3 | 91 |
| 27 | Yusmeiro Petit | CHC | ATL | June 10, 2008 | 12-0 | 9.0 | 0 | 4 | 0 | 1 | 7 | 91 |
| 28 | A.J. Wideman | COL | NYM | July 11, 2008 | 7-0 | 9.0 | 0 | 4 | 0 | 1 | 7 | 91 |
| 29 | Austin Bibens-Dirkx | COL | MIL | July 8, 2008 | 3-0 | 9.0 | 0 | 4 | 0 | 1 | 7 | 91 |
| 30 | Zach Stewart | CLE | CWS | July 2, 2008 | 3-0 | 9.0 | 0 | 4 | 0 | 0 | 5 | 91 |