| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Lucas Giolito | DET | CWS | April 9, 2022 | 1-0 | 9.0 | 0 | 0 | 0 | 1 | 14 | 106 |
| 2 | Clayton Kershaw | NYY | HOU | July 21, 2022 | 3-0 | 9.0 | 0 | 0 | 0 | 1 | 12 | 104 |
| 3 | Sandy Alcantara | DET | OAK | May 12, 2022 | 10-0 | 9.0 | 0 | 1 | 0 | 1 | 10 | 100 |
| 4 | Corbin Burnes | CIN | MIL | Sept. 10, 2022 | 4-0 | 9.0 | 0 | 2 | 0 | 0 | 9 | 99 |
| 5 | Julio Urias | MIA | PHI | Sept. 7, 2022 | 8-0 | 9.0 | 0 | 3 | 0 | 0 | 10 | 98 |
| 6 | Cole Hamels | MIL | MIN | July 13, 2022 | 7-0 | 9.0 | 0 | 2 | 0 | 1 | 10 | 98 |
| 7 | Chris Paddack | SD | PHI | June 23, 2022 | 0-5 | 9.0 | 0 | 2 | 0 | 2 | 12 | 98 |
| 8 | Carlos Rodón | DET | CLE | May 27, 2022 | 4-0 | 8.1 | 0 | 3 | 0 | 2 | 17 | 97 |
| 9 | Lance Lynn | CWS | KC | Aug. 9, 2022 | 2-0 | 9.0 | 0 | 1 | 0 | 2 | 9 | 97 |
| 10 | Max Scherzer | DET | TEX | Aug. 26, 2022 | 6-0 | 8.0 | 0 | 2 | 0 | 0 | 11 | 95 |
| 11 | Shane Bieber | MIA | NYM | Sept. 9, 2022 | 4-0 | 9.0 | 0 | 3 | 0 | 0 | 7 | 95 |
| 12 | Chris Bassitt | OAK | SEA | Sept. 21, 2022 | 4-0 | 9.0 | 0 | 4 | 0 | 0 | 9 | 95 |
| 13 | Julio Urias | MIA | TB | Aug. 30, 2022 | 0-1 | 9.1 | 0 | 5 | 0 | 0 | 9 | 95 |
| 14 | JT Brubaker | OAK | TEX | Sept. 13, 2022 | 4-0 | 8.0 | 0 | 2 | 0 | 1 | 12 | 94 |
| 15 | Shane Bieber | MIA | STL | April 20, 2022 | 4-0 | 8.0 | 0 | 1 | 0 | 2 | 12 | 94 |
| 16 | Shane Bieber | MIA | NYM | July 31, 2022 | 8-0 | 8.1 | 0 | 3 | 0 | 0 | 10 | 94 |
| 17 | Zack Wheeler | ATL | PHI | Sept. 23, 2022 | 5-0 | 9.0 | 0 | 2 | 0 | 0 | 4 | 94 |
| 18 | Steven Matz | STL | TOR | July 27, 2022 | 5-0 | 9.0 | 0 | 3 | 0 | 0 | 6 | 94 |
| 19 | Lucas Giolito | DET | MIN | Aug. 1, 2022 | 8-1 | 9.0 | 1 | 2 | 0 | 0 | 7 | 94 |
| 20 | Chris Bassitt | OAK | TEX | May 26, 2022 | 8-1 | 7.2 | 0 | 2 | 0 | 0 | 11 | 93 |
| 21 | Corbin Burnes | CIN | MIL | Aug. 7, 2022 | 7-0 | 8.0 | 0 | 2 | 0 | 1 | 11 | 93 |
| 22 | Luis Garcia | LAA | TEX | July 31, 2022 | 6-0 | 9.0 | 0 | 4 | 0 | 1 | 9 | 93 |
| 23 | Matthew Boyd | NYM | PIT | Sept. 15, 2022 | 1-0 | 8.0 | 0 | 3 | 0 | 0 | 10 | 92 |
| 24 | Tyler Mahle | COL | ATL | June 2, 2022 | 5-0 | 9.0 | 0 | 3 | 0 | 1 | 6 | 92 |
| 25 | Corbin Burnes | CIN | CLE | May 17, 2022 | 9-0 | 8.0 | 0 | 1 | 0 | 1 | 8 | 92 |
| 26 | Aaron Nola | TB | BAL | May 21, 2022 | 10-0 | 9.0 | 0 | 1 | 0 | 2 | 4 | 92 |
| 27 | Max Scherzer | DET | SD | July 26, 2022 | 3-0 | 7.0 | 0 | 1 | 0 | 1 | 14 | 92 |
| 28 | Walker Buehler | KC | CLE | April 9, 2022 | 8-0 | 8.0 | 0 | 1 | 0 | 1 | 8 | 92 |
| 29 | Joe Musgrove | CWS | CLE | July 22, 2022 | 4-0 | 8.0 | 0 | 3 | 0 | 0 | 10 | 92 |
| 30 | Griffin Canning | LAD | ARI | Sept. 20, 2022 | 2-0 | 7.0 | 0 | 1 | 0 | 1 | 13 | 91 |