| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Franmil Reyes | CWS | MIN | Oct. 3, 2022 | 11-1 | 5 | 4 | 9 | 3 | 3 | 0 | 127 |
| 2 | Paul DeJong | MIA | WSH | Sept. 16, 2022 | 18-9 | 4 | 3 | 7 | 2 | 3 | 2 | 110 |
| 3 | Juan Soto | MIA | ATL | May 29, 2022 | 20-4 | 6 | 4 | 7 | 2 | 3 | 1 | 109 |
| 4 | Anthony Rendon | SD | ARI | April 7, 2022 | 12-1 | 3 | 3 | 7 | 2 | 3 | 1 | 109 |
| 5 | Didi Gregorius | MIN | CLE | June 30, 2022 | 14-17 | 6 | 3 | 9 | 2 | 3 | 0 | 106 |
| 6 | Josh Donaldson | DET | MIN | May 30, 2022 | 12-0 | 4 | 3 | 6 | 2 | 4 | 1 | 105 |
| 7 | Greg Deichmann | CLE | NYY | April 23, 2022 | 10-11 | 5 | 3 | 8 | 2 | 3 | 0 | 103 |
| 8 | Brandon Lowe | KC | NYY | July 29, 2022 | 13-8 | 5 | 3 | 7 | 3 | 3 | 0 | 101 |
| 9 | Nolan Arenado | CHC | MIL | May 30, 2022 | 16-11 | 5 | 4 | 6 | 2 | 3 | 0 | 101 |
| 10 | Gosuke Katoh | TOR | STL | July 26, 2022 | 10-8 | 5 | 4 | 7 | 2 | 2 | 0 | 101 |
| 11 | Salvador Perez | MIL | CHC | Aug. 26, 2022 | 12-5 | 5 | 5 | 5 | 1 | 3 | 0 | 101 |
| 12 | Manny Machado | SF | WSH | April 23, 2022 | 12-3 | 5 | 3 | 7 | 3 | 3 | 0 | 101 |
| 13 | Manny Machado | SF | OAK | Aug. 6, 2022 | 14-11 | 5 | 5 | 5 | 1 | 3 | 0 | 101 |
| 14 | Fernando Tatis Jr. | DET | ARI | June 26, 2022 | 13-4 | 6 | 4 | 4 | 4 | 4 | 0 | 100 |
| 15 | Kyle Tucker | OAK | TEX | Aug. 16, 2022 | 12-9 | 4 | 4 | 4 | 2 | 2 | 3 | 99 |
| 16 | Mookie Betts | BAL | LAA | April 24, 2022 | 8-2 | 5 | 4 | 4 | 3 | 4 | 0 | 99 |
| 17 | Austin Riley | PHI | OAK | April 9, 2022 | 17-9 | 4 | 4 | 4 | 1 | 4 | 1 | 98 |
| 18 | Fernando Tatis Jr. | DET | MIN | April 26, 2022 | 12-3 | 6 | 4 | 6 | 2 | 3 | 0 | 97 |
| 19 | Christian Yelich | MIA | ATL | Sept. 2, 2022 | 18-8 | 6 | 5 | 4 | 1 | 4 | 0 | 97 |
| 20 | Rhys Hoskins | KC | DET | Sept. 11, 2022 | 7-5 | 4 | 3 | 5 | 3 | 3 | 1 | 96 |
| 21 | Mitch Garver | CWS | TOR | June 2, 2022 | 18-4 | 6 | 4 | 4 | 3 | 4 | 0 | 95 |
| 22 | Cedric Mullins | SF | ARI | July 5, 2022 | 19-1 | 6 | 5 | 4 | 2 | 3 | 0 | 95 |
| 23 | Vladimir Guerrero Jr. | MIA | ATL | Sept. 3, 2022 | 12-2 | 3 | 2 | 5 | 2 | 4 | 2 | 95 |
| 24 | Tommy La Stella | TEX | DET | June 18, 2022 | 6-7 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 25 | Max Kepler | TB | TOR | July 2, 2022 | 19-11 | 5 | 3 | 6 | 2 | 3 | 1 | 94 |
| 26 | Brandon Belt | SF | MIL | Sept. 8, 2022 | 9-0 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 27 | Vinnie Pasquantino | MIA | SEA | April 30, 2022 | 23-1 | 6 | 3 | 8 | 1 | 3 | 0 | 94 |
| 28 | Alex Bregman | NYM | MIL | Sept. 19, 2022 | 11-12 | 5 | 3 | 5 | 2 | 4 | 1 | 94 |
| 29 | Aaron Judge | LAD | COL | July 31, 2022 | 8-6 | 5 | 4 | 4 | 3 | 3 | 0 | 92 |
| 30 | Trent Grisham | SEA | TOR | May 18, 2022 | 13-6 | 5 | 4 | 3 | 2 | 4 | 1 | 92 |