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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sadler, Kyle | RP | Durham Bulls | 26 | 11/23/2055 | Lake Monticello | USA | Right | Right | 6' 4" | 200 lbs | - |
| Sai, Sirapat | 3B | Free Agent | 25 | 04/20/2057 | Lumby | CAN | Right | Right | 5' 11" | 190 lbs | - |
| Salazar, Terciero | 3B | Frederick Keys | 23 | 01/01/2059 | Tinaquillo | VEN | Right | Right | 6' 2" | 180 lbs | $580,000 |
| Sandoval, Ángel | RP | Fayetteville Woodpeckers | 26 | 01/18/2056 | San Francisco de Macorís | DOM | Right | Right | 6' 1" | 195 lbs | - |
| Schenkenberger, Nick | 3B | Asheville Tourists | 22 | 04/23/2060 | Des Moines | USA | Right | Right | 6' 4" | 190 lbs | - |
| Scribner, Tucker | C | Free Agent | 28 | 08/07/2054 | Saddle Brook | USA | Right | Right | 6' 0" | 200 lbs | - |
| Serno, Cedric | SP | Frederick Keys | 25 | 08/21/2057 | Dasmariñas | PHI | Right | Right | 6' 2" | 200 lbs | - |
| Shimizu, Shoudai | CF | Carolina Mudcats | 26 | 04/08/2056 | Koshoku | JPN | Left | Left | 6' 2" | 200 lbs | - |
| Sieni, Te | LF | Carolina Mudcats | 25 | 07/22/2057 | Tafuna | ASA | Right | Right | 6' 4" | 200 lbs | $580,000 |
| Simon, Jason | RP | Asheville Tourists | 23 | 10/13/2058 | Firestone | USA | Right | Right | 6' 3" | 195 lbs | - |
| Simonds, Par | 2B | Winston-Salem Dash | 22 | 09/03/2060 | Los Angeles | USA | Right | Right | 6' 1" | 170 lbs | - |
| Sonoda, Mitsuhisa | SP | Lynchburg Hillcats | 23 | 07/18/2059 | Kobe | JPN | Left | Left | 6' 1" | 180 lbs | - |
| Spears, Jonathan | CF | Durham Bulls | 26 | 11/12/2055 | Amesti | USA | Right | Right | 6' 4" | 200 lbs | - |
| Spiegel, Dillon | RP | Fayetteville Woodpeckers | 27 | 05/15/2055 | Shafter | USA | Left | Right | 6' 1" | 190 lbs | - |
| Sponville, Gustave | RP | Free Agent | 28 | 06/29/2054 | Compiègne | FRA | Right | Right | 6' 3" | 200 lbs | - |
| Steed, Wiley | 1B | Down East Wood Ducks | 22 | 04/26/2060 | Flagler Beach | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stevens, Gage | 2B | Bakersfield Badgers | 22 | 08/04/2060 | Winnsboro | USA | Right | Right | 6' 0" | 175 lbs | - |
| Story, Manfield | RP | Winston-Salem Dash | 24 | 06/18/2058 | Folsom | USA | Left | Right | 5' 10" | 165 lbs | - |
| Stowe, Dylan | RP | Carolina Mudcats | 24 | 01/12/2058 | Fairfield | USA | Left | Right | 6' 2" | 195 lbs | - |
| Strand, Roland | RF | Fayetteville Woodpeckers | 27 | 05/11/2055 | Highland Park | USA | Right | Right | 6' 1" | 200 lbs | - |
| Stubblefield, Dumbo | 2B | Durham Bulls | 23 | 04/16/2059 | Sacramento | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sukthed, Sarawut | SP | Asheville Tourists | 23 | 11/23/2058 | Quebec City | CAN | Right | Right | 6' 2" | 190 lbs | - |
| Szerencsi, Béla | RP | Fayetteville Woodpeckers | 26 | 02/06/2056 | Maroochydore-Mooloolaba | AUS | Right | Right | 6' 1" | 175 lbs | - |
