| # | Name | Team | Opp | Date | Score | AB | H | RBI | HR | R | BB | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rick Burleson | BOS | CWS | April 21, 1980 | 14-4 | 5 | 5 | 6 | 2 | 5 | 0 | 127 |
| 2 | Bobby Murcer | ML4 | OAK | Oct. 5, 1980 | 18-4 | 5 | 4 | 5 | 2 | 5 | 1 | 113 |
| 3 | Bobby Grich | CAL | BAL | Aug. 31, 1980 | 9-4 | 4 | 3 | 7 | 3 | 3 | 1 | 110 |
| 4 | Larry Hisle | BAL | OAK | June 18, 1980 | 14-7 | 4 | 4 | 6 | 3 | 3 | 0 | 110 |
| 5 | Leon Durham | NYM | ATL | May 25, 1980 | 7-2 | 4 | 4 | 6 | 3 | 3 | 0 | 110 |
| 6 | Wayne Gross | CWS | SEA | Sept. 17, 1980 | 11-6 | 5 | 4 | 6 | 3 | 3 | 0 | 106 |
| 7 | Greg Luzinski | PHI | NYM | Sept. 25, 1980 | 9-7 | 5 | 4 | 6 | 3 | 3 | 0 | 106 |
| 8 | Cliff Johnson | KC | NYY | May 13, 1980 | 18-7 | 6 | 5 | 4 | 2 | 4 | 0 | 102 |
| 9 | Garry Templeton | SD | PHI | June 15, 1980 | 15-3 | 6 | 5 | 5 | 0 | 4 | 0 | 99 |
| 10 | Cecil Cooper | DET | TOR | July 6, 1980 | 14-1 | 6 | 5 | 4 | 1 | 4 | 0 | 97 |
| 11 | Darrell Porter | DET | CAL | May 9, 1980 | 12-4 | 4 | 4 | 3 | 2 | 4 | 1 | 96 |
| 12 | Eddie Murray | BAL | CWS | July 11, 1980 | 9-3 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 13 | Eddie Murray | BAL | NYY | Aug. 16, 1980 | 10-5 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 14 | Dale Murphy | ATL | SD | April 30, 1980 | 10-0 | 5 | 4 | 4 | 2 | 4 | 0 | 94 |
| 15 | Chet Lemon | DET | TEX | Aug. 8, 1980 | 9-10 | 5 | 4 | 6 | 2 | 2 | 0 | 94 |
| 16 | Larry Parrish | HOU | SF | June 7, 1980 | 9-3 | 5 | 4 | 5 | 2 | 3 | 0 | 94 |
| 17 | John Stearns | MIN | NYY | May 3, 1980 | 14-1 | 4 | 3 | 7 | 1 | 2 | 1 | 93 |
| 18 | Keith Hernandez | STL | SF | July 29, 1980 | 16-1 | 4 | 4 | 4 | 0 | 3 | 2 | 91 |
| 19 | Wayne Gross | CWS | SEA | Sept. 16, 1980 | 9-3 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 20 | George Hendrick | PIT | PHI | May 28, 1980 | 10-3 | 4 | 3 | 5 | 2 | 3 | 1 | 91 |
| 21 | Willie Stargell | PIT | STL | April 17, 1980 | 9-0 | 4 | 4 | 3 | 2 | 4 | 0 | 91 |
| 22 | Jim Spencer | CIN | NYM | July 19, 1980 | 9-1 | 4 | 4 | 4 | 2 | 3 | 0 | 91 |
| 23 | Joe Ferguson | SD | CHC | May 18, 1980 | 7-6 | 6 | 4 | 5 | 2 | 3 | 0 | 90 |
| 24 | Clint Hurdle | SD | MON | June 11, 1980 | 16-2 | 6 | 4 | 5 | 2 | 3 | 0 | 90 |
| 25 | Sixto Lezcano | PHI | CHC | Oct. 2, 1980 | 10-1 | 3 | 2 | 4 | 2 | 4 | 2 | 88 |
| 26 | Reggie Smith | BOS | BAL | June 27, 1980 | 9-4 | 3 | 2 | 5 | 2 | 3 | 2 | 88 |
| 27 | Ron LeFlore | MIN | BAL | July 23, 1980 | 16-1 | 5 | 4 | 3 | 1 | 4 | 1 | 87 |
| 28 | Lance Parrish | PIT | SF | July 25, 1980 | 8-3 | 5 | 4 | 4 | 2 | 3 | 0 | 87 |
| 29 | Pat Kelly | MIN | BAL | June 1, 1980 | 18-4 | 4 | 3 | 5 | 1 | 3 | 1 | 86 |
| 30 | Eric Soderholm | CHC | PHI | Aug. 12, 1980 | 16-3 | 4 | 3 | 6 | 1 | 2 | 1 | 86 |