| # | Name | Team | Opp | Date | Score | IP | R | H | HR | BB | K | GS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tarik Skubal | BAL | TB | May 11, 2025 | 5-0 | 9.0 | 0 | 2 | 0 | 0 | 8 | 98 |
| 2 | Jakob Junis | KC | CHC | May 6, 2025 | 6-0 | 9.0 | 0 | 3 | 0 | 1 | 9 | 95 |
| 3 | Zac Gallen | AZ | NYM | May 8, 2025 | 6-0 | 9.0 | 0 | 3 | 0 | 1 | 8 | 94 |
| 4 | Triston McKenzie | CLE | CWS | March 28, 2025 | 11-0 | 9.0 | 0 | 2 | 0 | 1 | 6 | 94 |
| 5 | Freddy Peralta | MIL | ATL | April 5, 2025 | 4-0 | 8.1 | 0 | 2 | 0 | 1 | 10 | 94 |
| 6 | Shohei Ohtani | LAD | COL | March 30, 2025 | 8-1 | 8.1 | 1 | 3 | 0 | 0 | 11 | 92 |
| 7 | Cade Povich | DET | NYY | April 16, 2025 | 1-2 | 7.1 | 0 | 1 | 0 | 0 | 9 | 91 |
| 8 | Triston McKenzie | CLE | MIL | April 12, 2025 | 1-0 | 8.0 | 0 | 3 | 0 | 0 | 8 | 90 |
| 9 | Framber Valdez | HOU | TEX | April 8, 2025 | 11-1 | 9.0 | 1 | 5 | 0 | 0 | 8 | 89 |
| 10 | Jesus Luzardo | PHI | LAD | April 17, 2025 | 0-5 | 7.1 | 0 | 2 | 0 | 1 | 11 | 89 |
| 11 | Yu-min Lin | AZ | NYM | May 6, 2025 | 3-1 | 8.0 | 0 | 2 | 0 | 1 | 7 | 89 |
| 12 | Ricky Tiedemann | TOR | SD | April 21, 2025 | 13-1 | 9.0 | 1 | 4 | 0 | 2 | 9 | 88 |
| 13 | Jose Berrios | TOR | LAA | April 10, 2025 | 6-1 | 8.2 | 1 | 3 | 0 | 1 | 7 | 88 |
| 14 | Daniel Lynch | KC | TB | May 25, 2025 | 9-0 | 7.1 | 0 | 1 | 0 | 1 | 7 | 87 |
| 15 | Bryse Wilson | MIL | WSH | March 31, 2025 | 4-0 | 8.1 | 0 | 4 | 0 | 0 | 5 | 87 |
| 16 | Jose Berrios | TOR | AZ | April 27, 2025 | 4-1 | 8.1 | 1 | 2 | 0 | 1 | 6 | 87 |
| 17 | Tyler Mahle | CLE | TB | May 7, 2025 | 3-0 | 8.0 | 0 | 1 | 0 | 2 | 5 | 87 |
| 18 | Shota Imanaga | CHC | NYY | May 24, 2025 | 3-0 | 8.0 | 0 | 1 | 0 | 0 | 1 | 87 |
| 19 | Kyle Wright | PIT | NYY | April 21, 2025 | 3-2 | 7.0 | 0 | 1 | 0 | 1 | 8 | 86 |
| 20 | Aaron Civale | TB | NYY | May 16, 2025 | 2-0 | 7.2 | 0 | 3 | 0 | 1 | 8 | 86 |
| 21 | Logan Gilbert | SEA | WSH | April 14, 2025 | 1-0 | 7.1 | 0 | 2 | 0 | 2 | 10 | 86 |
| 22 | Max Fried | ATL | STL | April 26, 2025 | 4-0 | 8.0 | 0 | 4 | 0 | 1 | 8 | 86 |
| 23 | Pablo Lopez | MIN | CHC | April 3, 2025 | 4-0 | 8.0 | 0 | 3 | 0 | 1 | 6 | 86 |
| 24 | Luis Castillo | SEA | WSH | April 13, 2025 | 9-1 | 8.1 | 1 | 4 | 0 | 0 | 7 | 86 |
| 25 | Tanner Bibee | CLE | KC | April 15, 2025 | 1-0 | 8.0 | 0 | 1 | 0 | 2 | 4 | 86 |
| 26 | Wilmer Flores | DET | NYY | April 18, 2025 | 9-0 | 7.0 | 0 | 1 | 0 | 0 | 6 | 86 |
| 27 | JT Brubaker | PIT | OAK | May 6, 2025 | 4-3 | 7.0 | 1 | 1 | 0 | 1 | 10 | 85 |
| 28 | Jack Flaherty | NYM | PHI | May 11, 2025 | 6-1 | 9.0 | 1 | 5 | 0 | 1 | 6 | 85 |
| 29 | Chris Sale | ATL | NYM | May 19, 2025 | 2-3 | 8.0 | 1 | 3 | 0 | 2 | 10 | 85 |
| 30 | Jacob deGrom | TEX | HOU | April 14, 2025 | 5-0 | 7.0 | 0 | 2 | 0 | 1 | 9 | 85 |