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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Jaime | 1B | Mississippi Thrashers | 22 | 06/21/2056 | San Juan de los Morros | VEN | Left | Left | 6' 2" | 200 lbs | - |
| Salgado, Luís | RP | Birmingham Barons | 23 | 12/19/2055 | Yuma | USA | Right | Right | 6' 4" | 205 lbs | - |
| Samarripa, Nuno | SP | Pensacola Blue Wahoos | 24 | 05/24/2054 | Havana | CUB | Left | Left | 5' 11" | 175 lbs | - |
| Sana, Isaburo | RP | Free Agent | 24 | 03/12/2054 | Mihara | JPN | Right | Right | 6' 7" | 200 lbs | - |
| Sandoval, Elias | LF | Free Agent | 25 | 06/28/2053 | Santo Domingo | DOM | Right | Left | 6' 4" | 200 lbs | - |
| Sandoval, Félix | RP | Pascagoula Cannons | 29 | 03/01/2049 | Laredo | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sanford, Parker | SP | Pensacola Blue Wahoos | 24 | 12/12/2054 | Lehi | USA | Left | Right | 6' 1" | 195 lbs | - |
| Santiago, Jorge | SP | Free Agent | 27 | 08/02/2051 | Tenares | DOM | Left | Left | 6' 6" | 205 lbs | - |
| Schneck, Sebastian | 2B | Chattanooga Lookouts | 26 | 06/28/2052 | Los Banos | USA | Right | Right | 6' 0" | 195 lbs | - |
| Scholtz, Barry | 2B | Free Agent | 24 | 04/21/2054 | Brainerd | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sciarrone, Michael | 3B | Biloxi Shuckers | 25 | 01/27/2054 | Madison | USA | Right | Right | 6' 2" | 205 lbs | - |
| Segura, Ricardo | SP | Montgomery Biscuits | 22 | 03/09/2056 | San José | CRC | Left | Left | 6' 0" | 180 lbs | - |
| Sela, Elan | SP | Rocket City Trash Pandas | 24 | 11/08/2054 | San Diego | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sermrittirong, Khae | SP | Muscle Shoals Bears | 23 | 09/10/2055 | Ottawa | CAN | Right | Right | 6' 3" | 200 lbs | - |
| Shank, Randor | 2B | Rocket City Trash Pandas | 24 | 04/05/2054 | Rancho Cordova | USA | Right | Right | 6' 3" | 200 lbs | - |
| Shimomura, Tokaji | C | Free Agent | 28 | 12/23/2050 | Iwaki | JPN | Switch | Right | 6' 0" | 200 lbs | - |
| Shippen, Kaiden | RP | Pascagoula Cannons | 25 | 03/06/2053 | St. Paul | USA | Left | Left | 6' 2" | 195 lbs | - |
| Shivers, Gabriel | CL | Pascagoula Cannons | 23 | 10/23/2055 | Jackson | USA | Right | Right | 6' 5" | 195 lbs | - |
| Siam, Sanukran | SP | Mississippi Thrashers | 23 | 09/25/2055 | Halifax | CAN | Left | Left | 6' 1" | 180 lbs | - |
| Silva, Iván | 1B | Free Agent | 22 | 07/11/2056 | Manicaragua | CUB | Left | Left | 6' 2" | 190 lbs | - |
| Siriket, Thuanthong | RF | Biloxi Shuckers | 22 | 12/24/2056 | Toronto | CAN | Right | Right | 6' 0" | 190 lbs | - |
| Soares, Damião | RP | Birmingham Barons | 21 | 06/06/2057 | Turmero | VEN | Left | Left | 6' 4" | 195 lbs | - |
| Solis, Cody | SS | Free Agent | 28 | 11/13/2050 | Oxford | USA | Switch | Right | 6' 3" | 200 lbs | - |
| Somerville, Jacoby | RP | Montgomery Biscuits | 24 | 04/17/2054 | Rockwood | USA | Right | Right | 6' 2" | 195 lbs | - |
| Soto, Hugo | RF | Free Agent | 23 | 02/26/2055 | Matanzas | CUB | Left | Left | 6' 0" | 190 lbs | - |
| Spandler, Attila | LF | Rocket City Trash Pandas | 24 | 04/19/2054 | Melbourne | AUS | Right | Right | 6' 2" | 195 lbs | - |
| Spears, Jonathan | CF | Rocket City Trash Pandas | 23 | 11/12/2055 | Amesti | USA | Right | Right | 6' 4" | 190 lbs | - |
| Spooner, Larry | 3B | Birmingham Barons | 25 | 07/31/2053 | Hanford | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stanton, Rowan | RF | Mississippi Thrashers | 21 | 03/23/2057 | Kendallville | USA | Right | Right | 6' 1" | 185 lbs | - |
| Strange, Jerome | SP | Rocket City Trash Pandas | 22 | 11/18/2056 | Mesa | USA | Right | Right | 6' 1" | 195 lbs | - |
| Su, Jaxon | SS | Pascagoula Cannons | 28 | 04/21/2050 | Ben Avon | USA | Right | Right | 5' 11" | 195 lbs | - |
| Suazo, Adrián | SS | Pascagoula Cannons | 27 | 01/30/2052 | Chinandega | NCA | Right | Right | 6' 2" | 195 lbs | $580,000 |
| Sugiyama, Mao | 1B | Free Agent | 28 | 06/11/2050 | Kyoto | JPN | Left | Left | 6' 0" | 205 lbs | - |
| Sumalee, Mauseng | SP | Chattanooga Lookouts | 28 | 12/10/2050 | Sherbrooke | CAN | Right | Right | 6' 5" | 200 lbs | - |
| Sánchez, Franco | SP | Montgomery Biscuits | 25 | 09/05/2053 | New York | USA | Switch | Right | 6' 2" | 185 lbs | - |
