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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sagobe, Sugao | 2B | Bowie Baysox | 24 | 06/12/2058 | Kawachinagano | JPN | Right | Right | 5' 9" | 165 lbs | $580,000 |
| Salcedo, Hernán | SS | New Hampshire Fisher Cats | 24 | 02/04/2058 | Bayamón | PUR | Right | Right | 6' 1" | 195 lbs | - |
| Sanchez, Pablo | SP | Altoona Curve | 22 | 12/18/2059 | Havana | CUB | Left | Right | 6' 0" | 190 lbs | - |
| Sanford, Nikolai | CF | Santa Ana Walnut Growers | 23 | 05/29/2059 | Hillsville | USA | Left | Left | 6' 3" | 195 lbs | - |
| Sano, Benjamin | SP | Erie SeaWolves | 25 | 07/06/2057 | Evanston | USA | Right | Right | 6' 9" | 205 lbs | - |
| Santos, Hank | RP | Hartford Yard Goats | 23 | 11/17/2058 | Carrizo Springs | USA | Right | Right | 5' 10" | 175 lbs | - |
| Sanz, Martino | RP | Trenton Thunder | 28 | 09/10/2054 | Palo Negro | VEN | Right | Right | 6' 1" | 200 lbs | - |
| Sayago, Armando | SP | Portland Sea Dogs | 24 | 06/20/2058 | Santo Domingo | DOM | Right | Right | 6' 2" | 185 lbs | $580,000 |
| Scheiber, Randy | RP | Altoona Curve | 26 | 10/11/2055 | New York | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Schilling, Jimmy | CF | Akron RubberDucks | 27 | 11/03/2054 | Houston | USA | Left | Left | 5' 9" | 195 lbs | - |
| Schreiber, Shane | SP | New Hampshire Fisher Cats | 26 | 01/11/2056 | Houston | USA | Left | Left | 6' 2" | 200 lbs | $580,000 |
| Serrano, Christo | 2B | Akron RubberDucks | 27 | 07/13/2055 | Baní | DOM | Switch | Right | 6' 2" | 200 lbs | $580,000 |
| Serrano, Luís | 3B | Trenton Thunder | 27 | 11/14/2054 | Bayamón | PUR | Left | Right | 6' 1" | 195 lbs | - |
| Shearer, Mark | SP | Bowie Baysox | 26 | 03/18/2056 | Plymouth | USA | Right | Right | 6' 0" | 180 lbs | - |
| Sheets, Mick | 1B | Free Agent | 25 | 10/15/2056 | Freeport | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shine, Wynn | 3B | Bowie Baysox | 26 | 05/10/2056 | Redding | USA | Right | Right | 6' 1" | 200 lbs | - |
| Solarez, Bruno | CF | Portland Sea Dogs | 23 | 04/13/2059 | Banes | CUB | Right | Right | 6' 1" | 190 lbs | - |
| Solis, Mauricio | CF | Trenton Thunder | 26 | 01/11/2056 | Las Cumbres | PAN | Right | Right | 5' 11" | 175 lbs | $580,000 |
| Sonin, Timofei | 1B | New Hampshire Fisher Cats | 28 | 05/07/2054 | Volzhskiy | RUS | Left | Left | 6' 4" | 200 lbs | - |
| Spittler, Jim | SS | Binghamton Rumble Ponies | 21 | 12/09/2060 | Yonkers | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stephens, John | 3B | Bowie Baysox | 28 | 05/13/2054 | Hamtramck | USA | Right | Right | 6' 1" | 205 lbs | - |
| Stoltzfoos, Jonathan | C | New Hampshire Fisher Cats | 28 | 08/17/2054 | Amesbury | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sumalee, Naratorn | LF | Portland Sea Dogs | 26 | 03/11/2056 | Saint John | CAN | Switch | Right | 6' 5" | 200 lbs | - |
| Szoboszlay, Ede | LF | Free Agent | 28 | 12/01/2053 | Brisbane | AUS | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, J.B. | C | Santa Ana Walnut Growers | 25 | 03/02/2057 | San Cristóbal | VEN | Right | Right | 6' 0" | 200 lbs | $580,000 |
