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| Monday, December 31st , 2012 |
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| Signed free agent RP Scott Strickland to a 3-year contract worth a total of $10,000,000. |
| Monday, December 24th , 2012 |
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| Drafted SP Miles Mikolas in the 2012 Rule 5 Draft (Round 1, Pick 25, 25th overall Pick) from the Toronto Blue Jays. |
| Lost LF Adam Lind in the Rule 5 Draft to the New York Mets. |
| Lost LF Julian Martinez in the Rule 5 Draft to the Colorado Rockies. |
| Sunday, December 2nd , 2012 |
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| Traded 25-year old minor league C Salvador Brito to the Houston Astros, getting 18-year old minor league RF Elier Hernandez in return. |
| Sunday, November 25th , 2012 |
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| 2B Maicer Izturis becomes a free-agent. |
| C J.T. Wise received a 1-year contract through automatic renewal worth a total of $230,000. |
| 1B Chris Davis received a 1-year contract through automatic renewal worth a total of $230,000. |
| SP Clint Brannon becomes a free-agent. |
| SP Chris Tynan becomes a free-agent. |
| RP Scott Strickland becomes a free-agent. |
| SP Roberto Villegas received a 1-year contract through automatic renewal worth a total of $230,000. |
| 3B Jordan Padilla received a 1-year contract through automatic renewal worth a total of $230,000. |
| 1B Brandon Belt received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP Brad Thompson becomes a free-agent. |
| C Welington Castillo received a 1-year contract through automatic renewal worth a total of $230,000. |
| SP Rob Garza received a 1-year contract through automatic renewal worth a total of $230,000. |
| SP Jeremy Jeffress received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP John Hummel received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP Chris Cody received a 1-year contract through automatic renewal worth a total of $230,000. |
| CF Giampaolo Salimbeni received a 1-year contract through automatic renewal worth a total of $230,000. |
| RF Hector Martinez received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP Jaffet Morales received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP Hector Rondon received a 1-year contract through automatic renewal worth a total of $230,000. |
| C Travis Scott received a 1-year contract through automatic renewal worth a total of $230,000. |
| SP John Lackey becomes a free-agent. |
| RP Kenley Jansen received a 1-year contract through automatic renewal worth a total of $230,000. |
| SP Christian Friedrich received a 1-year contract through automatic renewal worth a total of $230,000. |
| RP Daniel Stange received a 1-year contract through automatic renewal worth a total of $230,000. |
| Friday, November 23rd , 2012 |
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| 2B Adam Jones was not offered arbitration, becomes a free agent. |
| RP Dallas Braden was not offered arbitration, becomes a free agent. |
| Tuesday, November 6th , 2012 |
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| Signed SS Alcides Escobar to a 10-year contract extension worth a total of $66,750,000. |
| Signed SP Chris Seddon to a 1-year contract extension worth a total of $1,700,000. |
| Signed 1B Bobby Lebron to a 1-year contract extension worth a total of $720,000. |
| Signed CF Austin Jackson to a 1-year contract extension worth a total of $5,170,000. |
| Signed SP Robert Mosebach to a 1-year contract extension worth a total of $1,410,000. |
| Signed SP Josh Outman to a 7-year contract extension worth a total of $43,300,000. |
| Signed RP Koji Uehara to a 1-year contract extension worth a total of $480,000. |
| Friday, November 2nd , 2012 |
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| Voided the team option year(s) of SP Chris Tynan for a buyout of $450,000. |
| Sunday, October 21st , 2012 |
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| Placed C J.T. Wise on the active roster. |
| Activated C J.T. Wise from the 60-day injured list. |
| Monday, September 10th , 2012 |
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| Purchased the contract of RP Jaffet Morales from Triple A Charlotte. |
| Purchased the contract of RP Hector Rondon from Triple A Charlotte. |
| Monday, September 3rd , 2012 |
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| Purchased the contract of SP Jeremy Jeffress from Triple A Charlotte. |
| Purchased the contract of RP Koji Uehara from Triple A Charlotte. |
| Purchased the contract of RP Chris Cody from Triple A Charlotte. |
| Purchased the contract of 1B Bobby Lebron from Triple A Charlotte. |
| Purchased the contract of CF Giampaolo Salimbeni from Triple A Charlotte. |
| Monday, July 30th , 2012 |
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| Placed C J.T. Wise on the 60-day injured list. |
| Purchased the contract of C Welington Castillo from Triple A Charlotte. |
| Optioned 1B Bobby Lebron to Triple A Charlotte. |
| Purchased the contract of 1B Chris Davis from Triple A Charlotte. |
| Monday, June 18th , 2012 |
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| Optioned C Welington Castillo to Triple A Charlotte. |
| Purchased the contract of C J.T. Wise from Triple A Charlotte. |
| Monday, April 16th , 2012 |
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| Assigned SP Travis Wood to Double A Birmingham. |
| Monday, April 9th , 2012 |
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| Optioned CF Giampaolo Salimbeni to Triple A Charlotte. |
| Placed CF Dave Krynzel on the active roster. |
| Monday, April 2nd , 2012 |
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| Assigned LF Adam Lind to Triple A Charlotte. |
| Optioned CL Koji Uehara to Triple A Charlotte. |
| Placed SP Clint Brannon on the active roster. |
| SP Travis Wood was designated for assignment and placed on waivers. |
| Saturday, March 31st , 2012 |
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| Signed free agent SP Clint Brannon to a 1-year contract worth a total of $2,000,000. |
| Thursday, March 29th , 2012 |
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| Demoted SP Juan Castillo to Triple A Charlotte. |
| Demoted SP Ramiro Cruz to Triple A Charlotte. |
| Demoted SP John Danks to Triple A Charlotte. |
| Demoted SP Ben Snyder to Triple A Charlotte. |
| Demoted SP Geoff Vandel to Triple A Charlotte. |
| Demoted RP Danny Barnes to Double A Birmingham. |
| Demoted RP Brad Boxberger to Double A Birmingham. |
| Demoted RP Oliver Drake to Double A Birmingham. |
| Demoted RP Victor Duarte to Triple A Charlotte. |
| Demoted RP Justin Grimm to Double A Birmingham. |
| Demoted RP Jose Valencia to Triple A Charlotte. |
| Demoted RP Jonny Venters to Triple A Charlotte. |
| Demoted 2B Joe Panik to Double A Birmingham. |
| Demoted SS Jose Iglesias to Double A Birmingham. |
| Demoted LF Griffin Benedict to Triple A Charlotte. |
| Demoted LF Carlos Puentes to Triple A Charlotte. |
| Demoted LF Seth Smith to Triple A Charlotte. |
| Demoted CF Antonio Berzoza to Triple A Charlotte. |
| Demoted RF Michael Zurita to Triple A Charlotte. |
| Optioned 2B Elian Herrera to Triple A Charlotte. |
| Optioned 1B Luis Gonzalez to Triple A Charlotte. |
| Optioned 1B Chris Davis to Triple A Charlotte. |
| Optioned C J.T. Wise to Triple A Charlotte. |
| Optioned SP Christian Friedrich to Triple A Charlotte. |
| Optioned SP Jeremy Jeffress to Triple A Charlotte. |
| Optioned SP Travis Wood to Triple A Charlotte. |
| Optioned RP Kenley Jansen to Triple A Charlotte. |
| Optioned RP Jaffet Morales to Triple A Charlotte. |
| Optioned RP Daniel Stange to Triple A Charlotte. |
| Optioned RP Hector Rondon to Triple A Charlotte. |
| Optioned RP Chris Cody to Triple A Charlotte. |
| CF Dave Krynzel was designated for assignment and placed on waivers. |
| Received former Rule 5 draft pick LF Adam Lind from the Arizona Firestorm. |
| Thursday, February 23rd , 2012 |
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| Recalled 2B Maicer Izturis from Triple A Charlotte. |
| Recalled RP Jaffet Morales from Triple A Charlotte. |
| Recalled RP Kenley Jansen from Triple A Charlotte. |
| Recalled SP Jeremy Jeffress from Triple A Charlotte. |
| Recalled C Welington Castillo from Triple A Charlotte. |
| Recalled 2B Elian Herrera from Double A Birmingham. |
| Recalled RP Hector Rondon from Winter Development League Mazatlan. |
| Recalled SP Christian Friedrich from Winter Development League Mazatlan. |
| Recalled SP John Lackey from Triple A Charlotte. |
| Recalled RP Daniel Stange from Triple A Charlotte. |
| Recalled SP Travis Wood from Triple A Charlotte. |
| Invited non-roster SP John Danks to Spring Training camp. |
| Invited non-roster LF Seth Smith to Spring Training camp. |
| Invited non-roster RF Michael Zurita to Spring Training camp. |
| Invited non-roster RP Jonny Venters to Spring Training camp. |
| Invited non-roster RP Victor Duarte to Spring Training camp. |
| Invited non-roster SP Geoff Vandel to Spring Training camp. |
| Invited non-roster LF Carlos Puentes to Spring Training camp. |
| Invited non-roster RP Danny Barnes to Spring Training camp. |
| Invited non-roster SP Ben Snyder to Spring Training camp. |
| Invited non-roster RP Jose Valencia to Spring Training camp. |
| Invited non-roster RP Oliver Drake to Spring Training camp. |
| Invited non-roster LF Griffin Benedict to Spring Training camp. |
| Invited non-roster CF Antonio Berzoza to Spring Training camp. |
| Invited non-roster SP Juan Castillo to Spring Training camp. |
| Invited non-roster SP Ramiro Cruz to Spring Training camp. |
| Invited non-roster RP Justin Grimm to Spring Training camp. |
| Invited non-roster RP Brad Boxberger to Spring Training camp. |
| Invited non-roster SS Jose Iglesias to Spring Training camp. |
| Invited non-roster 2B Joe Panik to Spring Training camp. |
