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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scott Strickland RP | 6 | 3 | 43 | 1.23 | 64 | 0 | 66.0 | 40 | 10 | 9 | 1 | 15 | 57 | 0.83 | .175 | .227 | 2.6 |
| Koji Uehara RP | 0 | 0 | 1 | 1.86 | 11 | 0 | 9.2 | 10 | 2 | 2 | 0 | 0 | 12 | 1.03 | .263 | .385 | 0.5 |
| Josh Outman SP | 13 | 8 | 0 | 2.55 | 30 | 30 | 187.0 | 124 | 53 | 53 | 4 | 73 | 167 | 1.05 | .188 | .243 | 5.1 |
| Dallas Braden RP | 5 | 2 | 1 | 3.13 | 45 | 0 | 60.1 | 51 | 22 | 21 | 7 | 19 | 47 | 1.16 | .227 | .256 | 0.1 |
| Clint Brannon SP | 11 | 5 | 0 | 3.14 | 30 | 30 | 183.1 | 165 | 68 | 64 | 15 | 38 | 135 | 1.11 | .240 | .277 | 3.7 |
| Rafael Soriano RP | 7 | 3 | 1 | 3.23 | 55 | 0 | 64.0 | 54 | 23 | 23 | 3 | 29 | 49 | 1.30 | .236 | .283 | 0.5 |
| Brad Thompson RP | 4 | 3 | 2 | 3.29 | 44 | 0 | 52.0 | 45 | 19 | 19 | 4 | 13 | 26 | 1.12 | .231 | .246 | -0.0 |
| Jaffet Morales RP | 0 | 0 | 0 | 3.38 | 2 | 0 | 2.2 | 2 | 3 | 1 | 0 | 2 | 2 | 1.50 | .182 | .222 | 0.0 |
| Chris Seddon SP | 16 | 7 | 0 | 3.49 | 30 | 30 | 185.2 | 162 | 80 | 72 | 19 | 63 | 136 | 1.21 | .238 | .267 | 2.0 |
| Robert Mosebach SP | 16 | 10 | 0 | 3.60 | 31 | 31 | 212.1 | 190 | 96 | 85 | 15 | 53 | 149 | 1.14 | .235 | .267 | 4.0 |
| Chris Tynan SP | 1 | 0 | 0 | 3.96 | 32 | 0 | 50.0 | 50 | 25 | 22 | 5 | 24 | 50 | 1.48 | .253 | .310 | 0.2 |
| Roberto Villegas SP | 4 | 1 | 3 | 4.07 | 53 | 0 | 79.2 | 71 | 37 | 36 | 5 | 26 | 61 | 1.22 | .236 | .278 | 0.7 |
| John Hummel RP | 1 | 4 | 2 | 4.43 | 39 | 0 | 42.2 | 47 | 21 | 21 | 5 | 9 | 28 | 1.31 | .285 | .313 | 0.1 |
| Rob Garza SP | 10 | 13 | 0 | 4.51 | 28 | 28 | 171.2 | 154 | 96 | 86 | 13 | 65 | 160 | 1.28 | .237 | .293 | 3.1 |
| John Lackey SP | 2 | 8 | 0 | 5.84 | 23 | 14 | 89.1 | 111 | 67 | 58 | 15 | 34 | 64 | 1.62 | .307 | .332 | -0.2 |
| Jeremy Jeffress SP | 0 | 0 | 0 | 7.94 | 6 | 0 | 5.2 | 5 | 5 | 5 | 1 | 4 | 3 | 1.59 | .263 | .267 | -0.2 |
| Chris Cody RP | 0 | 0 | 0 | 9.00 | 3 | 0 | 4.0 | 8 | 7 | 4 | 1 | 3 | 4 | 2.75 | .381 | .438 | -0.1 |
| Hector Rondon RP | 0 | 0 | 0 | 135.00 | 1 | 0 | 0.1 | 3 | 5 | 5 | 0 | 1 | 0 | 12.00 | .750 | .750 | -0.1 |
