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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Víctor Ramos# | 267.0 | 2006 | |
| 2 | Ubaldo Jimenez# | 262.0 | 2006 | |
| 3 | Mark Prior# | 261.0 | 2006 | |
| 4 | Cole Hamels# | 260.0 | 2008 | |
| 4 | John Thomson# | 260.0 | 2002 | |
| 6 | Mark Prior# | 257.0 | 2007 | |
| 7 | Dontrelle Willis# | 256.0 | 2006 | |
| 7 | Víctor Ramos# | 256.0 | 2003 | |
| 9 | John Thomson# | 253.0 | 2003 | |
| 10 | Jason Schmidt# | 252.0 | 2000 | |
| 11 | John Thomson# | 251.0 | 2001 | |
| 11 | Andy Pettitte | 251.0 | 2003 | |
| 13 | Dontrelle Willis# | 249.0 | 2007 | |
| 13 | Devin Gallegos# | 249.0 | 2008 | |
| 15 | Greg Maddux | 247.0 | 2000 | |
| 16 | Devin Gallegos# | 246.0 | 2003 | |
| 17 | Roy Halladay# | 243.0 | 2002 | |
| 18 | Andy Pettitte | 242.0 | 2001 | |
| 18 | Randy Wolf# | 242.0 | 2003 | |
| 20 | Derek Lowe# | 241.0 | 2000 | |
| 21 | Justin Verlander# | 240.0 | 2008 | |
| 22 | Ricky Nolasco# | 239.0 | 2008 | |
| 23 | Ricky Nolasco# | 237.0 | 2007 | |
| 24 | Matt Garza# | 236.0 | 2008 | |
| 24 | Devin Gallegos# | 236.0 | 2002 | |
| 26 | Derek Lowe# | 235.0 | 2003 | |
| 26 | Mark Prior# | 235.0 | 2008 | |
| 26 | Carl Pavano | 235.0 | 2000 | |
| 26 | Randy Wolf# | 235.0 | 2002 | |
| 30 | Kazuhisa Ishii | 234.0 | 2003 | |
| 30 | Randy Wolf# | 234.0 | 2006 | |
| 30 | Brandon Webb# | 234.0 | 2003 | |
| 30 | Víctor Ramos# | 234.0 | 2005 | |
| 34 | John Lackey# | 233.0 | 2005 | |
| 35 | Pedro J Martinez# | 232.0 | 2006 | |
| 35 | John Thomson# | 232.0 | 2000 | |
| 37 | Carl Pavano | 231.0 | 2003 | |
| 37 | Wandy Rodriguez# | 231.0 | 2003 | |
| 37 | Mark Mulder# | 231.0 | 2004 | |
| 40 | Justin Verlander# | 230.0 | 2007 | |
| 41 | Víctor Ramos# | 228.0 | 2004 | |
| 41 | Chris Carpenter# | 228.0 | 2008 | |
| 41 | Francisco Liriano# | 228.0 | 2008 | |
| 41 | Jeff Samardzija# | 228.0 | 2008 | |
| 41 | Cliff P Lee# | 228.0 | 2007 | |
| 46 | John Lackey# | 227.0 | 2001 | |
| 46 | Justin Verlander# | 227.0 | 2004 | |
| 46 | Justin Verlander# | 227.0 | 2006 | |
| 49 | Cliff P Lee# | 226.0 | 2008 | |
| 49 | Kazuhisa Ishii | 226.0 | 2006 | |
| 51 | Adam Wainwright# | 225.0 | 2008 | |
| 51 | Randy Wolf# | 225.0 | 2007 | |
| 51 | Brad Penny# | 225.0 | 2004 | |
| 51 | Randy Wolf# | 225.0 | 2005 | |
| 51 | Tim Lincecum# | 225.0 | 2008 | |
| 51 | Ricky Nolasco# | 225.0 | 2003 | |
| 57 | Erik Bedard# | 224.0 | 2006 | |
| 57 | Brad Penny# | 224.0 | 2003 | |
| 57 | Mark Mulder# | 224.0 | 2007 | |
| 57 | Rich Harden# | 224.0 | 2004 | |
| 61 | Devin Gallegos# | 223.0 | 2005 | |
| 61 | Brad Penny# | 223.0 | 2002 | |
| 61 | Ubaldo Jimenez# | 223.0 | 2008 | |
| 64 | Dallas Braden# | 222.0 | 2008 | |
| 64 | Andy Pettitte | 222.0 | 2002 | |
| 64 | Erik Bedard# | 222.0 | 2005 | |
| 64 | Jon Lester# | 222.0 | 2008 | |
| 68 | Carl Pavano | 221.0 | 2002 | |
| 69 | Tom Willis# | 220.0 | 2002 | |
| 69 | Kip Wells# | 220.0 | 2006 | |
| 69 | Derek Lowe# | 220.0 | 2006 | |
| 69 | Mark Prior# | 220.0 | 2004 | |
| 69 | Erik Bedard# | 220.0 | 2008 | |
| 69 | Jeff Samardzija# | 220.0 | 2007 | |
| 69 | Brad Penny# | 220.0 | 2007 | |
| 69 | Gavin Floyd# | 220.0 | 2005 | |
| 77 | Tim Lincecum# | 219.0 | 2006 | |
| 77 | Jae Weong Seo# | 219.0 | 2006 | |
| 77 | Jason Vargas# | 219.0 | 2006 | |
| 80 | Josh Beckett# | 218.0 | 2004 | |
| 80 | Dontrelle Willis# | 218.0 | 2008 | |
| 80 | Devin Gallegos# | 218.0 | 2000 | |
| 80 | Ryan Vogelsong# | 218.0 | 2008 | |
| 84 | Brett Tomko | 217.0 | 2001 | |
| 84 | Mark Mulder# | 217.0 | 2003 | |
| 84 | Rich Harden# | 217.0 | 2006 | |
| 84 | Cory Lidle | 217.0 | 2003 | |
| 84 | Brandon McCarthy# | 217.0 | 2008 | |
| 84 | Gerald Pittman# | 217.0 | 2003 | |
| 84 | Brad Penny# | 217.0 | 2005 | |
| 91 | Zack Greinke# | 216.0 | 2005 | |
| 91 | Corey Kluber# | 216.0 | 2008 | |
| 91 | Johan Santana# | 216.0 | 2003 | |
| 91 | Kirk Heap# | 216.0 | 2005 | |
| 91 | Mark Mulder# | 216.0 | 2005 | |
| 91 | Doug Davis# | 216.0 | 2003 | |
| 97 | Clayton Richard# | 215.0 | 2006 | |
| 97 | Justin Verlander# | 215.0 | 2005 | |
| 97 | Doug Davis# | 215.0 | 2004 | |
| 97 | Dontrelle Willis# | 215.0 | 2005 |
