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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Sandy Koufax | 5293 | 1956-1978 | |
| 2 | Satchel Paige* | 4496 | 1927-1946 | |
| 3 | Walter Johnson* | 4015 | 1907-1930 | |
| 4 | Nolan Ryan# | 3838 | 1967-1980 | |
| 5 | Don Drysdale | 3321 | 1956-1975 | |
| 6 | Sam McDowell | 3206 | 1962-1978 | |
| 7 | Dick Redding* | 3200 | 1911-1931 | |
| 8 | Steve Carlton# | 3168 | 1965-1980 | |
| 9 | Rube Waddell* | 3162 | 1901-1911 | |
| 10 | Mickey Lolich# | 3073 | 1963-1980 | |
| 11 | Bob Gibson* | 2964 | 1959-1974 | |
| 12 | Bob Feller | 2947 | 1936-1955 | |
| 13 | Gaylord Perry# | 2890 | 1962-1980 | |
| 14 | Charles Bender* | 2849 | 1903-1917 | |
| 15 | Lefty Grove* | 2838 | 1925-1941 | |
| 16 | Bullet Rogan* | 2827 | 1915-1929 | |
| 17 | Willie Foster* | 2788 | 1924-1941 | |
| 18 | Tom Seaver# | 2779 | 1967-1980 | |
| 19 | Don Sutton# | 2744 | 1966-1980 | |
| 20 | Jim Bunning* | 2741 | 1955-1970 | |
| 21 | Jim O'Toole | 2717 | 1958-1975 | |
| 22 | Eddie Plank* | 2635 | 1901-1915 | |
| 23 | Fergie Jenkins# | 2633 | 1965-1980 | |
| 24 | Roosevelt Davis* | 2631 | 1925-1945 | |
| 25 | Dean Chance | 2623 | 1961-1978 | |
| 26 | Ted Trent* | 2591 | 1927-1943 | |
| 27 | Willis Flournoy* | 2496 | 1919-1940 | |
| 28 | Jim Kaat | 2488 | 1960-1979 | |
| 29 | Andy Cooper* | 2459 | 1920-1934 | |
| 30 | Early Wynn | 2443 | 1939-1963 | |
| 31 | Whitey Ford | 2421 | 1950-1968 | |
| 32 | Juan Marichal | 2415 | 1960-1974 | |
| 33 | Joe Williams* | 2407 | 1911-1925 | |
| 34 | Christy Mathewson* | 2376 | 1901-1914 | |
| 35 | Luis Tiant# | 2340 | 1964-1980 | |
| 36 | Phil Niekro# | 2324 | 1964-1980 | |
| 37 | Jim Palmer# | 2315 | 1965-1980 | |
| 38 | Bob Veale | 2306 | 1962-1975 | |
| 39 | Curt Simmons* | 2289 | 1947-1967 | |
| 40 | Chris Short | 2278 | 1959-1974 | |
| 41 | Warren Spahn* | 2257 | 1942-1963 | |
| 42 | Chet Brewer | 2251 | 1926-1945 | |
| 42 | Rudy May# | 2251 | 1965-1980 | |
| 44 | Les Cain# | 2209 | 1968-1980 | |
| 45 | Hippo Vaughn* | 2195 | 1908-1923 | |
| 46 | Luis Tiant | 2154 | 1930-1946 | |
| 47 | Ray Sadecki | 2149 | 1960-1977 | |
| 48 | Ray Brown* | 2147 | 1931-1945 | |
| 49 | J.R. Richard# | 2138 | 1971-1980 | |
| 50 | Ed Walsh* | 2132 | 1904-1916 | |
| 51 | Bert Blyleven# | 2120 | 1970-1980 | |
| 51 | Leon Day | 2120 | 1934-1956 | |
| 53 | Al Downing | 2118 | 1962-1976 | |
| 53 | Jerry Koosman# | 2118 | 1967-1980 | |
| 55 | Billy Pierce | 2108 | 1948-1964 | |
| 56 | Doc White* | 2092 | 1901-1914 | |
| 57 | Smoky Joe Wood* | 2085 | 1908-1928 | |
| 58 | Robin Roberts* | 2080 | 1948-1966 | |
| 59 | Bob Turley | 2066 | 1952-1969 | |
| 60 | Bill Singer# | 2058 | 1966-1980 | |
| 61 | Wilbur Wood | 2047 | 1961-1979 | |
| 62 | Dazzy Vance* | 2044 | 1920-1935 | |
| 63 | Camilo Pascual | 2023 | 1955-1971 | |
| 64 | Carl Hubbell* | 2013 | 1928-1944 | |
| 65 | Jim Maloney | 2008 | 1960-1970 | |
| 66 | Andrew Foster* | 1994 | 1911-1924 | |
| 67 | Larry Dierker | 1990 | 1964-1977 | |
| 68 | Vida Blue# | 1979 | 1969-1980 | |
| 69 | Addie Joss* | 1975 | 1902-1918 | |
| 70 | Stan Williams | 1969 | 1958-1974 | |
| 71 | Barney Brown* | 1965 | 1931-1951 | |
| 72 | Joe Nuxhall | 1947 | 1949-1967 | |
| 73 | Dutch Leonard* | 1943 | 1913-1928 | |
| 74 | Bill McCall | 1942 | 1922-1938 | |
| 75 | Hal Newhouser | 1924 | 1939-1953 | |
| 76 | Tommy John# | 1900 | 1963-1980 | |
| 77 | Lefty Gomez | 1892 | 1930-1942 | |
| 78 | Steve Barber | 1891 | 1960-1975 | |
| 79 | Don Newcombe | 1883 | 1949-1968 | |
| 80 | Milt Pappas | 1864 | 1957-1975 | |
| 81 | Joe Coleman | 1852 | 1965-1979 | |
| 82 | Jose Mendez* | 1845 | 1911-1924 | |
| 83 | Eustaquio Pedroso | 1826 | 1911-1924 | |
| 84 | Rick Wise# | 1824 | 1965-1980 | |
| 85 | Gary Nolan# | 1818 | 1967-1980 | |
| 86 | Harvey Haddix | 1803 | 1952-1965 | |
| 87 | Denny Lemaster | 1799 | 1962-1976 | |
| 88 | Denny McLain# | 1754 | 1963-1980 | |
| 89 | Catfish Hunter | 1750 | 1965-1979 | |
| 90 | Larry Jackson | 1746 | 1955-1971 | |
| 91 | Red Ames | 1733 | 1903-1917 | |
| 92 | Jack Harshman | 1730 | 1953-1965 | |
| 93 | Jim Willis | 1723 | 1928-1943 | |
| 94 | Don Wilson | 1722 | 1966-1977 | |
| 95 | Red Ruffing | 1708 | 1924-1943 | |
| 96 | Pete Alexander* | 1693 | 1911-1924 | |
| 97 | Hilton Smith | 1691 | 1932-1942 | |
| 98 | Johnny Antonelli | 1684 | 1949-1962 | |
| 99 | Dave Brown* | 1681 | 1919-1929 | |
| 100 | Juan Pizarro | 1677 | 1957-1972 |
